Rat insular cortex and the amygdala kindling epilepsy model correlation.docVIP

 PAGE \* MERGEFORMAT 16 Rat insular cortex and the amygdala kindling epilepsy model correlation Study: Liu celebration Wang Feng, Mu Qingchun, Zhangpei Song, Xu in [Abstract] Objective Sprague-Dawley rats electrical stimulation of the insula, amygdala, and the same time stimulating the insular cortex, amygdala established model of complex partial seizures, the possibility of the island the pathogenesis of epilepsy. Methods 60 healthy male SD rats were randomly divided into three groups: the insular cortex kindling group (IK), amygdala kindling group (AK), while the nuclear island Ye Xingren kindling group (BK)., respectively, the left insula bipolar electrodes implanted in the left amygdala and both plant to enter the island Ye Xingren nucleus, after the release of the threshold determination to give twice a day after the electrical stimulation, stimulation parameters: intensity of 1.5 times after the release threshold, frequency 60 Hz, pulse width 1 ms, the duration of 1 s. Results insular cortex group and almonds threshold after the release of the nuclear group was significantly (P lt;0.05), time to ignition between the three groups was statistically significant, insula lit the fastest group, while the nuclear island Ye Xingren slowest fire kindled group (P lt;0.05), three groups showed no significant difference in lighting. Conclusion insula is an area of #8203;#8203;symptom onset epilepsy, the incidence of insular epilepsy, amygdala kindling development and there are differences, while igniting the fire performance of antagonism. [Keywords:] insula, amygdala, lighting, epilepsy model Abstract: Objective To stimulate Sprague Dawley Rat Insular, Amygdale or to stimulate insular and amygdale simultaneously and to establish Complicated Partial Epilepsy Model for investigating possible nosogenesis of Insular Epilepsy. Methods 60 male Sprague Dawley Rats were divided into 3 groups randomly: Insular kindling group ( IK), Amygdale kindling group (IK), I