RCBF of mild hypothermia on SAH and mortality in rats.docVIP

 PAGE \* MERGEFORMAT 12 RCBF of mild hypothermia on SAH and mortality in rats Of: Wang Baozhong, Lijun, Du Shulin [Abstract] Objective of mild hypothermia on subarachnoid hemorrhage (SAH) cerebral blood flow (rCBF) and mortality within 24 h and. Methods SD rats were divided into normal temperature group and the mild hypothermia group. Normothermia group puncture through the establishment of the anterior cerebral artery model of SAH, room temperature treatment; mild hypothermia group, rats were placed in the puncture will reduce the temperature to ice blanket (32 + -0.5) , 3 h after thawing at room temperature automatically. Determination of rat SAH within 2 h after the rCBF, calculated mortality within 24 h rats. Results at room temperature within 2 h after puncture group was significantly lower rCBF, 24 h mortality of 35.88% within; mild hypothermia group after 2 hours was significantly lower rCBF, but decreased the rate significantly reduced compared with SAH, 24 h mortality rate was 5.17% within. Conclusions Mild hypothermia can significantly improve the SAH rats rCBF, reducing the mortality within 24 h. [Keywords:] subarachnoid hemorrhage; regional cerebral blood flow; mortality; mild hypothermia Abstract: Objective To study the effects of mild hypothermia on regional cerebral blood flow (rCBF) and mortality rate within 24 hours after subarachnoid hemorrhage on rats.Methods SD rats were used as experimental animal and were respectively divided into normal thermal group and hypothermal group. Anterior cerebral artery perforation method was used to establish SAH rat model. Rats of hypothermia group were put onto ice blanket to degrade body temperature to (32 + -0.5) and automatically rewarmed under room temperature after 3 hours. rCBF of each group was determined in 2 hours after SAH. Calculate 24-hour mortality rate in each group.Results In normal thermal group, rCBF was significantly decreased in 2 hours after SAH and the mortality rate is 35.8