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receptor blockers in the clinical application of Cardiovascular Disease
PAGE \* MERGEFORMAT 16
receptor blockers in the clinical application of Cardiovascular Disease
[Keywords:] -blocker; old; cardiovascular diseases
-receptor blockers on sympathetic hyperthyroidism is the ideal blood pressure lowering drugs. But with the 2005 ESC (European Society of Cardiology) ASCOT results at the annual meeting and the formal announcement about the lack of -blockers lower blood pressure outside the target organ protection after the announcement of the experimental results, people in the past -blockers as first-line antihypertensive drugs have shaken the view. In fact -blockers in elderly patients with cardiovascular disease plays an important role .
1 -blocker profile
Present a more thorough study of myocardial tissue receptor 2, the 1, 2 receptors. Current clinical application of -blockers have 3 categories: categories: non-selective blockade of 1, 2 by body, such as propranolol (Inderal), sotalol (can be applied too), etc.; categories: selective blockade of 1 receptors, such as metoprolol (Betaloc), Atenolol (Atenolol), bisoprolol (Concord), etc.; categories: selective blockade of @ 1, receptor, such as carvedilol (Daly whole), arotinolol (Albert Markov), and Latin America Beiluo Er (labetalol may be) and so on, the clinical use of -blocker is required to master its 1, 2 receptor selective inhibition of soluble, peak time and half-life and so on.
Compared with other antihypertensive drugs, and different -blockers is very heterogeneous. Such as the role of receptor selective differences: 1 selectively higher on the bronchi and blood vessels more influence on the 2 receptor small, on glucose metabolism and lipid metabolism are also smaller; difference between fat soluble and water-soluble: fat-soluble -blockers through blood-brain barrier, complete oral absorption, short half-life, a certain treatment advantage. In addition, different -blockers also have significant differences in hemodynamics: Atenolol reduced cardiac out
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