Renin - angiotensin system and kidney inherent in the relationship between phenotype transformation.doc

 PAGE \* MERGEFORMAT 11 Renin - angiotensin system and kidney inherent in the relationship between phenotype transformation Abstract renin - angiotensin system in the renal tubular - interstitial injury and glomerular sclerosis plays an important role in the process, through the large number of experiments found that the renin - angiotensin system in renal cell phenotypic transformation processes have a definite impact for understanding the progression of lesions blocking the process of the law and find an entry point to provide a certain basis. Keywords: renin - angiotensin system; renal cell phenotype; Review Inflammatory glomerular disease emergence and development of “first, because cytokine imbalance,” and then produce intrinsic kidney cells phenotype, thereby causing tubular - interstitial renal tubular injury and glomerular sclerosis - interstitial injury and renal hardening of the ball, eventually leading to renal outcome [1]. In recent years, in almost all of the renal disease models and the consensus of the majority of clinical studies confirm that blocking the renin - angiotensin system RAS will definitely delay the progress of kidney disease. RAS by renin, angiotensinogen, angiotensin Ⅰ (Ang Ⅰ), angiotensin-converting enzyme (ACE), angiotensin Ⅱ (Ang Ⅱ) and angiotensin receptor (ART) such as six major ingredients, which Ang Ⅱ as a major bio-active peptides. The system’s role in kidney disease related to kidney diseases almost every aspect of the process, but the most important thing is caused by hemodynamic disorders, water and salt metabolic disorders and the promotion of renal disease progression [1]. Inherent in a kidney cell phenotype Cells in a specific physiological and pathological conditions of the form, structure and function change, called phenotypic conversion, also called trans-differentiation to differentiation. In the chronic progress of the process of change, due to the continuing role of pathogen