Research Progress of antifungal agents.docVIP

 PAGE \* MERGEFORMAT 12 Research Progress of antifungal agents 【Key Words】 antifungal agents;,, multi-vinyl;,, triazole;,, echinocandin class Abstract: Over the past 20 years, with the application of a large number of broad-spectrum antibiotics, bone marrow and organ transplantation, corticosteroids and immunosuppressive agents in the application of the increase in the incidence of AIDS, all kinds of catheter intervention and fungal detection techniques improved, candidemia and systemic Aspergillus infections on the rise. Beijing Union Medical College Hospital reported in four different decades sepsis, blood culture results showed that from 1994 to 1995 the incidence of fungal 81%; in 2000 to 67%. 20 years, 149 cases of fungal infection analysis showed that fungal infection showed a rising trend year by year. Already on the clinical fluconazole-resistant Candida and Aspergillus-resistant amphotericin B, there is. Therefore, the need for new antifungal agents. Are about to launch and has been listed drug are: multi-vinyl liposomes of nystatin, amphotericin B liposome formulations AmBisome, amphotericin B liposome complex Abelect, amphotericin B colloid dispersions Amphotec, itraconazole oral solution and injection agent, voriconazole injections and oral tablets, as well as caspofungin injections. A variety of new drugs has its own characteristics and adverse reactions, but the overall is the development of new drugs and clinical applications, will provide a strong invasion of fungal infections of the treatment measures, the prospects for the treatment of fungal infections will be further improved. Keywords: antifungal; more vinyl; triazole; echinocandin class In the past two decades, along with the application of a large number of broad-spectrum antibiotics, bone marrow transplants carried out, corticosteroid and immunosuppressive agent applications, catheter interventional treatment, especially in the AIDS epidemic, candidemia and syste