Resistance protein expression and tumor differentiation of the chemical treatment of the relationship between the individual Progress.docVIP

 PAGE \* MERGEFORMAT 13 Resistance protein expression and tumor differentiation of the chemical treatment of the relationship between the individual Progress [Abstract] multi-drug resistant tumor cells leading to the production of the main reasons for failure of cancer chemotherapy. Resistance protein in different individuals the expression of tumor tissue differentiation. Resistance protein expression pattern is to determine the sensitivity of a cancer chemotherapy a very important indicator. study and detection of such differentially expressed, a reasonable choice of personalized treatment programs, to improve the success rate of chemotherapy, the tumor has important clinical significance. [Key Words] multi-drug resistance drug resistance associated proteins, antineoplastic combined chemotherapy, the tumor program Drug resistance-associated protein is the product of gene expression, including P glycoprotein (P-gp, multidrug resistance protein (MDR-associated protein, MRP, LRP (lung resistance-related protein, LRP, topological differences allosteric enzyme (Topo , glutathione S transferase (GST and so on. expressions of multidrug resistance gene and its product-mediated drug efflux by intracellular changes in detoxification enzymes and other mechanisms of multidrug resistance in tumor cells (multiple drug resistance, MDR mechanisms play an important role. Resistance protein expression differences, is characterized by resistance proteins determine the sensitivity of cancer chemotherapy, a very important indicator. Early clear resistance protein in different individuals of different tumor tissues, is to select the appropriate individual treatment programs, to avoid failure of chemotherapy, an important part of improving patient survival. Resistance protein 1 expression in tumor tissues Study confirmed that the resistance protein has been found in HCC showed high expression state, in HCC, adjacent tissues and normal tissues tend to show the