Retinoblastoma matosis RB1 gene mutations in human cells detection of.docVIP

 PAGE \* MERGEFORMAT 10 Retinoblastoma matosis RB1 gene mutations in human cells detection of Author: Sheng Xun-lun, Wu Weimin, Zhuangwen Juan, Yung-Ning, Wang Juan, Xia Mei-hua, Zhang Ling 【Abstract】 Objective To detect the retinoblastoma (RB) patients in the RB1 gene mutations in somatic cells to explore the RB1 gene mutations in the molecular biological mechanism. PCR-SSCP technique leukocyte genomic screening for RB patients DNA, sequencing to determine mutation. Results in 12 patients with RB, RB1 gene identified three cases of germ cell mutations. They are the first T in ex