RF-positive and negative patients with rheumatoid arthritis CD4 + cells in peripheral blood gene expression differences.docVIP

 PAGE \* MERGEFORMAT 12 RF-positive and negative patients with rheumatoid arthritis CD4 + cells in peripheral blood gene expression differences Of: Lu Cheng, XU Shijie, Xiao Cheng, Yan Xiaoping, Zhao Linhua, Wang Jianming, Li shoot, TRADITIONAL [Abstract] Objective: To study the RF-negative RA factor positive patients and whether there was difference in genomics, probing gene expression differences. Methods: The gene expression profiling methods to detect these two types of patients with CD4 + lymphocyte gene expression. Results: RF factor positive and 55 negative patients gene expression between the difference was statistically significant. Conclusion: RF-negative RA factor positive patients with differentially expressed genes between these differentially expressed genes associated more with the immune response. [Keywords:] rheumatoid arthritis, rheumatoid factor gene expression Rheumatoid arthritis (rheumatoid arthritis, RA is inflammation around the joint symmetry-based, with repeated episodes of chronic systemic disease, patients in the joints of up to 60% partial disability, is a serious self-harm to human health autoimmune disease, its etiology is not yet clear, mainly genetic, infection, hormones, immune factors, and other related [1]. Recent studies show that: RA of the occurrence and development of changes in CD4 lymphocytes is closely related to the infiltration of synovial CD4 + T lymphocytes of autoantigen-specific immune response generated to promote monocyte-macrophage cells, activation of nuclear cytotoxic T cell differentiation, leading to inflammatory cytokine release, formation of inflammatory injury. rheumatoid factor (rheumatoid factor, RF is diagnosis and treatment of RA during one of the most commonly used test, it is about RA, the positive rate of 60% to 80%, but low specificity [2, 3]. To inquire RA, RF negative and positive patients the existence of differences between gene expression, we used gene chip technology in periphe