Research on the pathogenesis of bronchial asthma status.docVIP

 PAGE \* MERGEFORMAT 12 Research on the pathogenesis of bronchial asthma status [Keywords:] bronchial asthma With industrialization, widely carried out, bronchial asthma has become a major disease in most industrialized countries [1]. The past 20 years, bronchial asthma morbidity and mortality continue to increase, the global number of patients with bronchial asthma, more than 300 million. China’s mortality rate in patients with bronchial asthma than 30/10 million, the highest in the world. Bronchial asthma (bronchial asthma, referred to as asthma) is a variety of cells (such as eosinophils, mast cells, T lymphocytes, neutrophils, airway epithelial cells, etc.) and cellular components (cellular elements) involved in the gas Road chronic inflammatory disorders [2], its pathogenesis has not been fully clarified. Asthma is essentially a kind of allergic airway inflammation, airway of the basic pathological change mast cells, lung macrophages, eosinophils, lymphocytes and neutrophil infiltration. Airway submucosal edema, microvascular permeability increase in bronchial secretions storage to stay within the bronchial smooth muscle spasm, fibro-epithelial peeling, exposing the basement membrane, goblet cell proliferation and increase in bronchial secretions and other pathological changes, the main pathological features are eosinophils (EOS) consisting mainly of allergic airway inflammation [3]. Its main feature is the total serum IgE levels and specific IgE levels increased. In recent years, research on the pathogenesis of asthma deepening of various research and test results varied, even contradictory. Now on the helper T cell 1 (helper T cell 1, Th1) / Th2, and CD4 CD25 regulatory T cells (CD4 CD25 Tr) in the pathogenesis of asthma research in an overview of the status quo. 1 Th1/Th2 balance theory 1.1 Th1 and Th2 differentiation of bronchial asthma in recent years, immunological studies suggest that the immunological pathogenesis of asthma as the ratio betwe