RFC in the treatment of 1 case of macroglobulinemia F.docVIP

 PAGE \* MERGEFORMAT 7 RFC in the treatment of 1 case of macroglobulinemia F [Keywords:] RFC program macroglobulinemia F Fahrenheit macroglobulinemia (Waldenstrm macroglobulinemia, WM) are mature malignant plasma cells proliferative disease, mainly plasma cells in bone marrow samples in lymphocytes and tumor cells synthesized a wide range of monoclonal IgM.WM Expression of CD20 antigen. using anti-CD20 monoclonal antibody rituximab in combination with fludarabine, cyclophosphamide RFC program consisting of treatment of the disease with satisfactory results. 1 Clinical data Patients, male, aged 57, began treatment a year ago no incentive fatigue, loss of appetite, heart palpitations after the event, often feel dizzy, 2 months ago began to frequent cough, sputum, diagnostic clinics in the community as a “lung infection”, after anti-infective treatment cough, expectoration improved, but weakness, dizziness, performance did not improve at the same time, the family found pale. our hospital laboratory hemoglobin 73 g / L, with anemia of unknown income homes. disease process without bone and joint pain. admission examination: moderate anemia appearance, the skin was no bleeding, no yellow dye, does not touch superficial lymph nodes, sternum without tenderness, liver not palpable, spleen and large, locked middle ribs 6.5 cm, no tenderness. Laboratory tests: Hb 70 g / L, Ret 0.048, WBC 5.2 109 / L (Category L = 0.73, PLT 313 109 / L, ESR 145 mm / s 1 h, urinary Rt (-, plasma viscosity scale value (mPas2.65 (normal reference value of 1.46 ~ 1.80. Bone marrow: hyperplasia, G 34.5%, E 13.5%, G / E 2.56:1, mature red blood money was cord-like arrangement of cells increased the proportion (48.5% shows that plasma cells like lymphocytes (12%, such cell body sizes, some of the edge is not the whole cell body, nucleus deviation, chromatin condensation, barely visible nucleoli, plasma blue, 38 megakaryocytes, showing that middle board 15 megakaryocytic and platelet