Rho family proteins in tumor invasion and metastasis in the role of.docVIP

 PAGE \* MERGEFORMAT 22 Rho family proteins in tumor invasion and metastasis in the role of Keywords: malignant tumor Invasion and metastasis is an important characteristic of malignant tumors, but also patient mortality. Human studies on the mechanism of tumor metastasis has been 100 years of history, with the gene regulation of tumor metastasis multi-stage, multi-factor, multi-step theory of continuous improvement, for this complex pathological process has been more in-depth understanding. Discovered and confirmed with a high degree of tumor metastasis-related genes become hot mechanism of tumor metastasis, because these genes and their products may become a new cancer target for anti-metastasis treatment or observation in patients with an important prognostic indicator. Rho family of Ras superfamily proteins are the first to be cloned protein, they are a group of relative molecular mass of about 20 ~ 25kD of guanosine triphosphate (guanosine triphosphate, GTP)-binding protein with a GTP activity, therefore, used to known as the Rho GTP enzyme, Rho GTP enzyme in regulation of cytoskeletal reorganization plays an important role 〔1〕. Recent studies found that, Rho GTP enzyme is highly expressed in many cancers, and the incidence and cancer, invasion and metastasis. In this paper, from the tumor cell morphological changes, cell and extracellular matrix adhesion and cytoskeletal reorganization, and several other aspects of the Rho GTP enzyme in tumor invasion and metastasis of the molecular regulation mechanisms are summarized below. 1 Rho GTP enzyme So far, Rho GTP enzyme superfamily has been found that about 20 members, according to the structure and function of different, can be divided into five sub-families, including: (1) Rho subfamily, including RhoA, RhoB, and RhoC, in a sequence that has a high degree of homology, and is highly expressed in a variety of cells, mainly involved in tension-fiber formation and focal adhesion complexe