Rhodiola on Alzheimers disease in rats on behavior and brain antioxidant capacity of_0.docVIP

 PAGE \* MERGEFORMAT 13 Rhodiola on Alzheimer’s disease in rats on behavior and brain antioxidant capacity of Of: Jijun Hu, Dong Union Ling, Cao Juan, CARDIO-/CEREBROVASCULAR, Wang Jian [Abstract] Objective Rhodiola on Alzheimer’s disease (AD) model rats and mechanism of the effect of interference. Methods intraperitoneal injection of D-galactose (paired with saline concentration 10 mg / mL) and irrigation stomach AlCl3 (dubbed concentration with distilled water, 20 mg / mL), and the establishment of a one-time injection of scopolamine in AD animal models. through the Morris water maze test systems detect changes in learning and memory in rats, anti-superoxide anion and the determination of total antioxidant capacity was detected group of antioxidant levels in brain tissue, routine HE staining and immunohistochemical expression of Aβ1-40 test, rats morphological changes in hippocampus and cortex. by way of Rhodiola in rats fed intervention and Hydergine as controls to observe the intervention effects. Results of model rats was significantly impaired memory function, nerve cell damage significantly, the hippocampus and the cortex of β-amyloid protein deposition and senile plaques. Chinese medicine group medicine group and control group rats water maze test, the escape latency was significantly shorter, than the original platform quadrant, marked increase in the number of cross-platform, and the model group were significantly (P lt;0.05), model group, anti-superoxide anion and total antioxidant activity than other was significantly lower (P lt;0.05). Conclusion Rhodiola can improve spatial learning and memory in rats AD damage, while scavenging free radicals and oxidative damage have a significant effect, have neuroprotective effects. [Keywords:] Rhodiola, Alzheimer disease, behavior, antioxidant capacity, rat Abstract: Objective To study the intervention effect and mechanism of integripetal rhodiola herb (IRH) on Alzheimer’s disease model rats. Metho