Resistance of Klebsiella pneumoniae.docVIP

 PAGE \* MERGEFORMAT 8 Resistance of Klebsiella pneumoniae Of: Wu Wei Yuan Li Honglin Lu Yuemei Wu Jinsong Liu Hsia [Abstract] Objective To compare the production of extended spectrum -lactamases (ESBLs) producing Klebsiella pneumoniae and non-ESBLs strains of drug resistance. Methods 1 December 2007, Shenzhen People’s Hospital separation of hospitalized patients with pneumonia Craig Job strain 76. by KB method susceptibility testing them, ESBLs confirmed by CLSI (Clinical Laboratory Standards Committee) recommended by the phenotypic confirmatory disk diffusion test. Results All isolates were sensitive to imipenem, production strains of antibiotic resistance enzyme higher than non-enzyme production strains, enzyme production strains were resistant to piperacillin and 100% of cefaclor. Conclusions of the drug resistance of Klebsiella pneumoniae serious, lactam antibiotics and enzymes inhibitor combination therapy, amikacin, cefoxitin, and drugs to control hydrocarbon production mold vinyl ESBLs Klebsiella pneumoniae infection. [Keywords:] Klebsiella pneumoniae, ESBLs, resistance to antibiotics in clinical use with the continuous increase in bacterial resistance is increasingly serious, especially gram-negative bacteria produce extended spectrum -lactamases (extended spectrum lactamases, ESBLs) and the prevalence of drug resistance caused by a clinical focus. ESBLs are plasmid mediated and led by the bacteria to penicillins, first, second, third and fourth generation cephalosporins and antibiotic resistance of single ring a class of enzymes, such enzymes mainly by Klebsiella pneumoniae (klebsiella pneumoniae, KP) and Escherichia coli produce [1]. ESBLs producing strains were resistant to broad spectrum often appears as multiple drug resistance. Therefore, the understanding of these microbial of drug resistance, the treatment plan, the rational use of antimicrobial agents is of great significance. In this paper, Shenzhen People’s Hospital patients 1