Rhubarb treatment of chronic renal failure study of the active ingredients.doc

 PAGE \* MERGEFORMAT 15 Rhubarb treatment of chronic renal failure study of the active ingredients 【Abstract】 Objective of medicinal rhubarb chronic renal failure study the chemical constituents. Methods chromatography and spectroscopy in the extraction and isolation and identification of chemical constituents of rhubarb (-)  epigallocatechin  3  o  gallate (EGCG), and through oral giving right nephrectomy-induced renal failure rat model of treatment, observation of animals in each group blood urea nitrogen and serum creatinine levels. Results EGCG can reduce the renal failure rat model of blood urea nitrogen and serum creatinine levels and lower glomerular membrane injury index, and with a certain amount of drug dose-effect relationship . Conclusion on chemical constituents of medicinal rhubarb EGCG can kidney structure and physiological function near normal. Keywords: chemical constituents of rhubarb renal failure Study on the Chemical Constituent of Rhubarb in the Treatment of Chronic Renal Failure Abstract: ObjectiveTo study the chemical constituent of rhubarb in the treatment of chronic renal failure. MethodsChromatographic and spectral technologies were used to extract, separate and elucidate the chemical constituent EGCG.Treat the kidney in the mouse model through giving orally, observes each group of animal urea nitrogen and the serum myo  anhydride content.ResultsThe level of urea nitrogen in the blood and serum myo  anhydride decrease.EGCG reducd the renal glomerulus’s membrane damage index.ConclusionThe chemical constituent EGCG of rhubarb can protect and repair the kidney organic function. Keywords:: Medical rhubarb; Kidney failure; Chemical compostion Chronic renal failure (Chronic Renal Failure, CRF) is a variety of renal diseases, the ultimate outcome of continued progress, but to stop its progress is still the most concern clinicians and patients one of the issues. The treatment of CRF include