Risperidone and perphenazine in the treatment of senile schizophrenia.doc

 PAGE \* MERGEFORMAT 7 Risperidone and perphenazine in the treatment of senile schizophrenia Of: Luai Yi, Cao Yongkang, Pan Yu Biao [Abstract] Objective To compare risperidone and perphenazine for schizophrenia and old age security. Methods 68 elderly patients with schizophrenia were randomly divided into two groups, respectively, risperidone or perphenazine treatment of 8 weeks, both groups before and after treatment in the treatment of 2,4,8 weekend with the Positive and Negative Syndrome Scale (PANSS and adverse Symptom Scale (TESS [1] assessed the efficacy and adverse reactions. Results efficient risperidone group 82.4%, perphenazine group was 76.5%, the two groups showed no significant clinical differences (Pgt; 0.05, risperidone group 8 weeks after treatment of negative symptoms sub-group was significantly lower than perphenazine, perphenazine group than in less adverse reactions and light. Conclusion risperidone and perphenazine in the treatment of senile schizophrenia clinical efficacy equivalent, but the negative symptoms of risperidone treatment on efficacy and safety superior to perphenazine. [Keywords:] risperidone in schizophrenia in old age perphenazine New atypical antipsychotic drugs on positive and negative symptoms are a therapeutic effect, and adverse drug reaction, in the treatment of mental illness more and more attention. In this paper, perphenazine as a control to compare risperidone in elderly of the efficacy and safety of schizophrenia, are as follows. Subjects and Methods 1. Objects All patients from our hospital in January 2007 to 12 months of outpatient or hospitalized patients, are in line with the Chinese Classification and Diagnostic Criteria of Mental Disorders Version 3 (CCMD 3 diagnostic criteria of schizophrenia, agegt; = 60 years old, male or female , 1 week before enrollment did not use antipsychotic medication, PANSS total scoregt; = 60 points, excluding a serious physical illness, alcohol or drug abuse