Scar tissue in the rat CGRP VEGF expression and significance of the changes.docVIP

 PAGE \* MERGEFORMAT 11 Scar tissue in the rat CGRP VEGF expression and significance of the changes Of: Zhou Jianqing, Yong-Zhong Wang, Jiang Hongyan [Abstract] Objective: To evaluate the wound tissue of calcitonin gene-related peptide (CGRP, vascular endothelial growth factor (VEGF expression and the correlation between injury time. Methods: immunohistochemistry, image analysis techniques in the dynamic detection of scar tissue in rats CGRP, VEGF expression. Results: The lifetime trauma group (1,2,4,8,12,24 h CGRP in rat skin tissue in the nerve fibers was significantly higher than the normal control group (P lt;0.05, dead rats CGRP expression in skin tissue compared with normal control group, no significant change (Pgt; 0.05. CGRP expression in the injured group alive after injury significantly increased 1 h, 4 h reached a peak, 8 h began to decrease, then gradually returned to normal. VEGF in 8 h after injury in the skin begin to express, 72 h expressed the strongest (P lt;0.01), 96 h began to decline. Conclusion: CGRP expression in injured tissue significantly earlier than VEGF, but also the regularity of the time, can be used as an early wound injury time estimation of the important indicators. [Keywords:] rats, calcitonin gene-related peptide, vascular endothelial growth factor, immunohistochemistry [Abstract] Objective: To investigate the relationship of the time of injury and the expressions of calcitonin gene related peptide (CGRP) and vascular endothelial growth factor (VEGF) in rat’s skin after injury. Methods: The expressions of CGRP and VEGF in the wound tissue were detected by immunohistochmisty technique and MIAS image analysis system. Results: The expression of CGRP in neurofibrils in the wound tissue (1,2,4,8,12,24 h) was higher than that in the control (P lt; 0.05). However, in postmortem injury group, there were no significant changes in anti CGRP immounreactivities in neurofibrils compared to the control group (Pgt; 0.05). Furthe