Schisandrin Shengmaisan in the pharmacokinetics study.docVIP

 PAGE \* MERGEFORMAT 10 Schisandrin Shengmaisan in the pharmacokinetics study [Abstract] Objective To study the Shengmaisan Schisandrin in drug metabolism in rats in vivo kinetics. Methods Rats were fed for Shengmaisan 2.16 g / kg, at different time points blood samples using HPLC determination schisandrin The change of concentration in order to 3p97 pharmacokinetic analysis software to calculate pharmacokinetic parameters. Results schisandrin in rats in vivo pharmacokinetic parameters were: t1 / 2 (Ka) of 0.245 h, t1 / 2 (Ke) of 1.506 h, T (peak) to 0.767h, Cmax of 0.926 mg * L -1, AUC to 2.863 mg * L-1 * h-1. Conclusion Shengmaisan Schisandrin be absorbed into the body, its rate of absorption and elimination in the body than those faster, consistent with linear kinetics. [Keywords:] Shengmaisan; schisandrin; pharmacokinetics; rat; efficient solution Abstract: ObjectiveTo study the pharmacokinetics of schizandrin in Shengmai powders in normal rats. MethodsAfter ig administration of the drug (2.16 g / kg) for the rats, the plasma was collected at different time points. The schizandrin in Shengmai powders and in the plasma were analyzed by HPLC.Pharmaconetic parameters were calculated from the plasma concentration-time data with the 3p97 software package.ResultsThe main pharmacokinetic parameters were as follows: t1 / 2 (Ka) was 0.245 hour, t1 / 2 (Ke) was 1.506 hour, T (peak) was 0.767 hour, Cmax was 0.926 mg * L-1, AUC was 2.863 mg * L-1 * h-1.ConclusionThe schizandrin in Shengmai powders can be absorbed into body, and its absorption and elimination is rapid.The pharmaconetics of plasma schizandrin complies with linear kinetic course. Keywords:: Shengmai powders; Schisandrin; Pharmacokinetics; Rats; HPLC Jin Zhang Shengmaisan the first element found in the ‘medical Kai source’, is a famous ancient Chinese medicine one of the parties, from ginseng, Ophiopogon, Schisandra composition for the treatment of ‘lung ambush fire, pulse gas-stricken’, in or