SDF1-CXCR4 with bone marrow stem cell transplantation for treatment of stroke.doc

 PAGE \* MERGEFORMAT 20 SDF1/CXCR4 with bone marrow stem cell transplantation for treatment of stroke Keywords:: bone marrow ancestral cells; cerebral vascular accident; chemotactic factor; receptor, CXCR4; cell movement Bone marrow stem cells (BMSC) in many tissues and organs show great potential for cell differentiation, its treatment of stroke become the research hotspot. BMSC can be induced ischemia is known to mobilize domestic and foreign-derived stem cells can “feel” tissue damage and the directional migration to the damage zone and conduct differentiation. BMSC plasticity, differentiation and migration depend on the role of local micro-environment of injured tissue-specific signals. Recent studies have recognized some of the specific molecular signals, in particular, stromal cell-derived factor 1 (SDF1) and its specific receptor, CXCR4, in BMSC interaction with the damaged tissue, and migration play an important role in the process. The author of the recent SDF1/CXCR4 in BMSC migration to the ischemic brain tissue in the role of research to be reviewed, in order to better explore the stem cell treatment of stroke to provide reference. 1 BMSC transplantation for the treatment of stroke Stem cells with multiple differentiation potential, can self-renew and to depend on their micro-environment where the proliferation and differentiation into many types of cells. Many different types of stem cells, such as those from peripheral blood, bone marrow and embryonic stem cells in a variety of experimental animal models of focal cerebral ischemia successfully used to induce nerve regeneration and functional restoration [15]. Fetal sources of neural stem cells within the brain by direct injection or intra-arterial injection can be successfully transplanted to reach the brain tissue damage. However, due to immune rejection of allogeneic stem cell transplant can only survive a short time [6]. In the focal cerebral ischemic inju