人工合成抗菌药26513.pptVIP

Synthetic antimicrobial;Classification ;Quinolones;Classification of quinolnes;The first-generation -nalidixic acid（1962）;The first-generation (nalidixic acid,萘啶酸) （1962）;The second-generation (pipemidic acid,吡哌酸)（1973）;The third-generation -fluoroquinolones （1980s）;Fluoroquinolones ;First generation;Antibacterial activity;Mechanism of action;1.2 Mechanism of action;1.2 Mechanism of action;1.2 Mechanism of action;;;1.2 Mechanism of action;1.2 Mechanism of action;Only for bacteria ;;Pharmacokinetics ;Resistance ;Mechanism of resistance;Clinical application;Adverse reaction;Contraindication [k?ntr?,indikei??n]禁忌症 ;Common fluoroquinolones in clinic;Ciprofloxacin [,sipr?ufl?ks?sin]环丙沙星 The strongest antibacterial action in vitro Bioavailability is 38-60% Strong effect for G- bacilli and drug-resistance G+/G– Therapeutic application is mainly for infections of other drug resistance G- bacilli. No effect for most anaerobian. ;The same antibacterial character to ciprofloxacin In addition, ofloxacin has effect for mycobacterium tuberculosis,chlamydia trachomatis and some anaerobian. The second-line agent for treatment of tuberculosis Levofloxacin Its antibacterial activity is double of ofloxacin’s. ; good absorption by oral administration Its bioacailability is about 99%. Distributed widely in body fluids and tissues Strong antibacterial activity in vivo Adverse reaction is more.;Ⅱ Sulfonamides  Trimethoprim ;Introduction;2.1 Antibacterial spectrum ;2.2 Mechanism of action;2.2 Mechanism of action;2.3 Therapeutic applications;2.4 Adverse effects