Sleep deprivation Danhong injection on learning and memory in rats_0.docVIP

 PAGE \* MERGEFORMAT 15 Sleep deprivation Danhong injection on learning and memory in rats OF: Secretary Jiang Hua, Yang L, DEFENDING, Qu Chuan Yong, Zhangming Lei, WANG Yan-ping, Fan Lei [Abstract] Objective Danhong injection (Danhong injection) on the sleep deprivation (sleep deprivation, SD) of learning and memory and hippocampal GFAP (Glial Fibriliary Acidic Protein, GFAP) expression. Methods of water with a small platform SD model for the establishment of environmental law. selected Wistar rats, according to SD on the time of (0 ~ 5 d), were randomly divided into 6 groups, each group was divided into experimental and control group, the experimental group were given Danhong injection, the corresponding time point of each group rats Morris water maze test, detected by immunohistochemistry in the hippocampus of GFAP content. Results ① Morris water maze test: 2,3,5 d incubation group, the experimental group than the control group (P lt;0.05) , 4 d incubation group, the experimental group than the control group (P lt;0.01); 2, 5 d group to swim away, the experimental group than the control group (P lt;0.05), 3,4 d group swimming distance in the experimental group than the control group (P lt;0.01); SD group at each time point the number of crossing the platform, the experimental group and control group no significant difference (Pgt; 0.05). ② hippocampal GFAP levels: 2, 3 d GFAP content in the hippocampus, the experimental group than the control group (P lt;0.05), 4,5 d GFAP content in the hippocampus, experimental group was higher (P lt;0.01). Conclusion Danhong injection on learning and memory in SD rats after damage to a protective role, which may be associated with the hippocampus astrocytes (astrocyte, AS) function activation. [Keywords:] Danhong injection; sleep deprivation; learning and memory; glial fibrillary acidic protein; Morris water maze Abstract: ObjectiveTo investigate the effect of Danhong injection on cognitive function and the con