TRP channels are involved in the molecular mechanisms of temperature sensation.docVIP

 PAGE \* MERGEFORMAT 22 TRP channels are involved in the molecular mechanisms of temperature sensation [Abstract] the body through the temperature sensor to sense temperature changes and external environment in recent years has clearly transient receptor potential (transient receptor potential, TRP) channels play an important role in temperature sensation, including thermal sensation mediated TRPV1, TRPV2, TRPV3, TRPV4 and TRPM8-mediated cold feeling and TRPA1, TRP channels are involved in this to feel the effect of temperature, the molecular mechanism of several TRP channels are reviewed. [Keywords:] Transient receptor potential; TRP channel; temperature sensor [Abstract] Living organisms can sense temperature changes in environmental and internal temperature by thermoreceptor. Recently it is confirmed that transient receptor potential (TRP) channels play an important role in mediating temperature sensation, including TRPV1, TRPV2, TRPV3 and TRPV4, which are concerned with warm sensation, and TRPM8 and TRPA1 concerned with cold sensation. This article reviewed the molecule mechanism of TRP channel participating in temperature sensation. [Keywords:] transient receptor potential; TRP channel; thermoreceptor temperature sensing mechanism is still a long time concern of scientists a subject [1]. Recent studies have found that transient receptor potential (transient receptor potential, TRP) is present in the cell membrane or intracellular organelle membrane ion channel superfamily, a class of proteins, the TRPC, TRPV, TRPM, TRPML, TRPP, TRPA, TRPN other seven sub-family composition [1,2]. TRP family of TRPV Received Revised 20,090,608 20,090,702 About Han Qin (1982), female, County of Sichuan Province who, Director, Research Institute, the Master, research direction: natural immunity and inflammation. E mail: quneiy520@ Subfamily members of TRPV1, TRPV2, TRPV3, TRPV4, TRPM and TRPA subfamily members of the subfamily members of TRPM8 and TRPA1 feel