Tumor hypoxia Progress in radiation-sensitizing agents.docVIP

 PAGE \* MERGEFORMAT 20 Tumor hypoxia Progress in radiation-sensitizing agents [Keywords:] tumor; lack of oxygen; radiation sensitizer The results show that tumor growth is disordered growth, angiogenesis, insufficient, so most of human solid tumors, there is a lack of oxygen region, the region of the tumor cell resistance to ionizing radiation, oxygen content of the normal capacity of more than 2 or 3 tumor cells times, the main reason is to reduce the proliferation of oxygen free radicals damage DNA [1]. solid tumor hypoxia is the main reason for the failure of radiotherapy, to overcome the lack of oxygen caused by the radiation resistance is to improve cancer treatment is an important way. [ 1]. In the past decade, scientists have proposed many methods to overcome tumor hypoxia caused by the radiation resistance [1-2]. The first measure is the increase in radiation when the oxygen content of tumor tissue, including hyperbaric oxygen therapy, oral tobacco amide and the inhalation of oxygen and carbon dioxide gas mixture of 5% of treatment [2]. Drug B C Xi Luo [3] the use of oxygen diffusion to enhance the ability of tumor hypoxia, is a synthetic allosteric modifier of hemoglobin . endothelin B receptor agonist use, it can selectively increase tumor blood supply. The second strategy is directed at targeting hypoxic cells and hypoxic cells of drug-sensitizing agents, including sugar glycolysis inhibitors, biological reduction of cytotoxic activity [1-2,4], and the third channel is targeting the HIF-1 drug. HIF-1 is a lack of oxygen can improve tumor cell survival rate of transcription factor [5]. Recent research progress is mainly concerned with the latter two strategies. A hypoxic cell sensitizer These compounds are a class of pro-active structure of the nitro aromatic electron compounds, the structure can participate in the biological reduction of hypoxic cell metabolism. It could weaken the role of nitro analog of oxygen, thus weakening the ra