持续静脉滴注氟尿嘧啶联合顺铂治疗晚期头颈部癌.pdfVIP

《中@矗森森，t)) 2007 :if第 17 卷第9 期 716 CHINA ONCOLOGY 2007 Vo l. 17 No.9 持续静脉滴注氟尿嗦咙联合)1顷钧 治疗晚期头颈部癌 罗志国常建华于慧日月湾提问华郭畔李进 上海 200032 复旦大学附属肿瘤跟皖肿嘀内科， [摘襄] 背景与阳的;}I因锦与氟尿峨院是治疗晚期头颈部肿瘤疗效确切的药物，但有 A 定的毒性反应。本研 究观察持续静脉滴注氟f7R略院联合}I附自治疗晚期头颈部癌的疗效及安全性。方法;22 例晚期头颈部癌患者给予氟 尿畸院750 mg/ (m2 • d) 持续静脉滴注5 d(120 h) ，顺铅 25 mg/ (m2 • d) ,dl -3 0 21 d 为一个周期，2 个周期后评价 疗效。结果:CR 1 例(4.5% ) ,PR 8 例(36.4%) ，近期客观有效率为 40.9% (9/22) 。中位ITP 7.4 个月， 1 2 72.7% 。初治与复治有放率分别为75.0% (6/8) ,2 1. 4% (3/14) ， 统计学盏界有显著性(x :::6.04 ， P0.05) 。 、胃肠道反应和粘膜炎。结论:持续静脉滴注瓶尿暗院联合}I阪铀治疗晚期头颈部癌具有 较好的疗效，安全性，好。 [关键词] 头颈部肿瘤; 氟尿峪院; 顺销; 晚期; 化学治疗 中图分类号:民730.53 文献标识码:A 文章编号:1ω7-3639(2∞7 )09 -D716-D3 Analysis of chemotherapy with 5-FU by continons intravenous infusion and cisplatin in head and neck advanced cancer LUO Zhi-guo, CHANG Jian扣ω， YU H町， LV Fangjang , WU Xiang-hua , GUO Ye, Ll Jin (Department 01Medical Oncology, Cancer Hospital , Fudan University, Department o/On- cology, Shαnghai Medical College, Fudan Universtiy, Shanghai 200032, Chinαj Co汀espond坛， nce to: CHANG Jian-huα E-mαil: chαngjiαnhua@163. com [Abstract] Background and purpose: Cisplatin and 5-fluorouracil (5-FU) have demonstrated significant activity in patient鸣 with advanced head and neck cancer despite relevant toxicity. We evaluated the efficacy and toxicity of combination chemotherapy using continuous intravenous infusion 5-FU plus ci叩latin for locally advanced , recurrent ,