儿童睡眠中癫痫性电持续状态的诊疗进展.pdfVIP

·综 述· 中国现代医生 2016 年 4 月第 54 卷第 11 期 儿童睡眠中癫痛性电持续状态的诊疗进展 莫庭庭 洪思琦 A 重庆医科大学附属儿童医院神经内科，重庆 4∞014 [摘要 l 儿童睡眠中癫痛性电持续状态 (ESES) 是儿童时期一种特殊的脑电图现象，常见于多种癫痛综合征，其中 以 LKS 、 ABECTS ， CSWS 为主。 ESES 这种持续、异常的癫痛性放电可导致患儿不同程度的神经心理损伤，如认知 障碍、学习障碍、精神行为异常等，影响患儿的日常生活质量。本文就近年国内外关于儿童睡眠中癫痛性电持续 状态的脑电图表现特点、病因及发病机制、神经心理损伤及相关治疗进展做一综述。 [关键词]儿童;睡眠中癫瘸性电持续状态;脑电围;神??心理损伤 [中图分类号] R742.1 [文献标识码] A [文章编号] 1673-9701(2016)11-0164-05 The recent progress of electrical status epilepticus during sleep in children MO Tin侈ing HONG Siqi Department of Neurology,the Children Hospital of Chongqing Medical University, Chongqing 400014, China [Abstract] Electrical status epilepticus during sleep (ESES) is a peculiar electroencephalography pattern in children, characterized by paroxysmal activity signifjcantly activated during sleep, typically in the period of NREM (non-rapid eye movement). ESES is related to various epilepsy syndromes, especially common in landau -Kleffner syndrome, ABECTS, and CSWS, which results in neuropsychological impairment. This article is aim to review the recent progress in the fjeld of electroencephalogram (EEG ), pathogenesis, neuropsychological impairme时， and treatment of ESES. [Key words] Children; Electrical status epilepticus during sle叩; Electroencephalogram; Neuropsychological impairment 儿童睡眠中癫痛性电持续状态 (electrical status 1 ESES 定义及脑电图表现 epilepticus during sleep , ESES) 是→种儿童时期特殊 ESES 指在非快速眼动睡眠期 (non-rapid eye move? 的脑电图现象。 1971 年 Pat町等首先报道此种现象， ment ， NREM) 出现的1. 5-2.5 Hz 持续或接近持续的癫 并指出 ESES 与认知功能障碍密切相关。有统计表 痛样放电。 ESES 是一种脑电图现象， 1977 年由 Tassi- 明， ESES 约占癫瘸患儿的 0.