热疗在消化道肿瘤综合治疗中的地位讲述.pptx

热疗在消化道肿瘤综合治疗中的地位;;;消化道肿瘤治疗主要手段;肿瘤热疗发展了500年——走向精准;磁共振温度成像;温度场磁共振成像;Pennes Bioheat Equation（潘尼斯生物热物理公式） ;NRL-X采用温场核磁共振成像指导下相位阵列射频聚焦加热的三维适形深部肿瘤热治疗;美国Pyrexar公司的BSD3000;美国 INSIGHTEC公司磁共振引导下的HIFU;热疗联合放疗;热疗联合化疗;热疗联合放化疗;;;;;化疗联合热疗治疗食管癌的Meta 分析;Study Design ;primary tumor response: 31 (39.7%) exhibited a complete response (CR) of the primary lesions, 43 (56.4%) exhibited a partial response (PR) and 3 (3.9%) cases exhibited stable disease (SD). The total response rate (CR + PR) of the primary tumor to the trimodal treatment was as high as 96.1%.;小结;;图像引导下的热消融;MR引导下的HIFU消融;;;;结果：;119例不能手术切除肝转移结直肠癌患者;结果;结论;;腹腔热灌注化疗简史;腹腔热灌注化疗的药物选择;腹腔热灌注化疗的药物选择;;腹膜恶性肿瘤行肿瘤细胞减灭术联合腹腔热灌注化疗的疗效;;;;;;结论;Tristan D A Systematic Review and Meta-analysis of the Randomized Controlled Trials on Adjuvant Intraperitoneal Chemotherapy for Resectable Gastric Cancer. Annals of Surgical Oncology 2007.14(10):2702–2713;PF 方案联合顺铂腹腔热灌注化疗术后辅助化疗 治疗局部晚期胃癌的临床研究;Results: Clinical data of patients;DFS;;Results: Adverse reactions;小结;;OPTIMA研究;使用纳米热敏脂质体包裹化疗药物，利用温度控制脂质体内药物释放;;;结果;;晚期胃癌腹水中分离的Exosomes加热后诱导肿瘤特异性CTL细胞应答;癌性腹水中高速离心分离出来的Exosomes;Cytokine secretion;CIK细胞腹腔热灌注治疗晚期肝癌;结果：;TTP and OS;;Hyperthermia effects on Hsp27 and Hsp72 associations with mismatch repair (MMR) proteins and cisplatin toxicity in MMR-deficient/proficient colon cancer cell lines;;结果;;小结;;Thank You For Your Attention!