Comparative functional analysis of Jembrana disease virus Tat protein on lentivirus long terminal repeat promoters evidence for flexibility at its N-terminus.docVIP

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Comparative functional analysis of Jembrana disease virus Tat protein on lentivirus long terminal repeat promoters evidence for flexibility at its N-terminus.doc

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Comparative functional analysis of Jembrana disease virus Tat protein on lentivirus long terminal repeat promoters evidence for flexibility at its N-terminus

Virology Journal BioMedCentral Research Open Access Comparative functional analysis of Jembrana disease virus Tat protein on lentivirus long terminal repeat promoters: evidence for flexibility at its N-terminus Yang Su1,2, Gang Deng1,2, Yuanming Gai1,2, Yue Li1,2, Yang Gao1,2, Jiansen Du1,2, Yunqi Geng1,2, Qimin Chen1,2 and Wentao Qiao*1,2 Address: 1Key Laboratory of Molecular Microbiology and Biotechnology (Ministry of Education), College of Life Sciences, Nankai University, Tianjin 300071, China and 2Key Laboratory of Microbial Functional Genomics (Tianjin), College of Life Sciences, Nankai University, Tianjin 300071, China Email: Yang Su - tenlions@; Gang Deng - foolduck@; Yuanming Gai - sangny1234@; Yue Li - liyue_pg@; Yang Gao - gaoyang875@; Jiansen Du - djs916@; Yunqi Geng - gengyq@; Qimin Chen - qmchen@; Wentao Qiao* - wentaoqiao@ * Corresponding author Published: 28 October 2009 Received: 20 September 2009 Accepted: 28 October 2009 Virology Journal 2009, 6:179 doi:10.1186/1743-422X-6-179 This article is available from: /content/6/1/179 ? 2009 Su et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Jembrana disease virus (JDV) encodes a potent regulatory protein Tat that strongly stimulates viral expression by transactivating the long terminal repeat (LTR) promoter. JDV Tat (jTat) promotes the transcription from its own LTR as well as non-cognate LTRs, by recruiting host transcription factors and facilitating transcriptional elongation. Here, we compared the sequence requirements of jTat for transactivation of JDV, bovine immunodeficiency virus (BIV) and human immunodeficiency virus (HIV) LTRs. Results: In this study, we identified the minimal protein sequence for LTR acti