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Comparative analysis of full genomic sequences among different genotypes of dengue virus type 3.doc

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Comparative analysis of full genomic sequences among different genotypes of dengue virus type 3

Virology Journal BioMedCentral Research Open Access Comparative analysis of full genomic sequences among different genotypes of dengue virus type 3 Chwan-Chuen King1, Day-Yu Chao*2, Li-Jung Chien3, Gwong-Jen J Chang4, Ting-Hsiang Lin3, Yin-Chang Wu3 and Jyh-Hsiung Huang3 Address: 1Institute of Epidemiology, College of Public Health, National Taiwan University, Taipei, Taiwan(10020), PRoC, 2Institute of Veterinary Public Health, College of Veterinary, National Chung-Shin University, Taipei, Taiwan(402), PRoC, 3Center for Disease Control, Department of Health, Taipei, Taiwan (100), PRoC and 4Division of Vector-Borne Infectious Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), Fort Collins, Colorado (80521), USA Email: Chwan-Chuen King - cc_king99@.tw; Day-Yu Chao* - dychao@.tw; Li-Jung Chien - Chien@; Gwong- Jen J Chang - gxc7@; Ting-Hsiang Lin - thlin@.tw; Yin-Chang Wu - ycw@.tw; Jyh-Hsiung Huang - jhh@.tw * Corresponding author Published: 21 May 2008 Received: 28 January 2008 Accepted: 21 May 2008 Virology Journal 2008, 5:63 doi:10.1186/1743-422X-5 -63 This article is available from: /content/5 /1/63 ? 2008 King et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Although the previous study demonstrated the envelope protein of dengue viruses is under purifying selection pressure, little is known about the genetic differences of full-length viral genomes of DENV-3. In our study, complete genomic sequencing of DENV-3 strains collected from different geographical locations and isolation years were determined and the sequence diversity as well as selection pressure sites in the DENV genome other than within the E gene were also analyzed. Re