Comparative analysis of somitogenesis related genes of the hairyEnhancer of split class in Fugu and zebrafish.docVIP

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Comparative analysis of somitogenesis related genes of the hairyEnhancer of split class in Fugu and zebrafish.doc

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Comparative analysis of somitogenesis related genes of the hairyEnhancer of split class in Fugu and zebrafish

BMC Genomics BioMedCentral BMC2002Genomics, 3 Research article x Comparative analysis of somitogenesis related genes of the hairy/ Enhancer of split class in Fugu and zebrafish Martin Gajewski* and Chris Voolstra* Address: Universitaet zu Koeln, Institut fuer Genetik, Weyertal 121, 50931 Koeln, Germany E-mail: Martin Gajewski* - martin.gajewski@uni-koeln.de; Chris Voolstra* - chr.voolstra@uni-koeln.de *Corresponding authors Published: 5 August 2002 Received: 11 June 2002 Accepted: 5 August 2002 BMC Genomics 2002, 3:21 This article is available from: /1471-2164/3/21 ? 2002 Gajewski and Voolstra; licensee BioMed Central Ltd. This article is published in Open Access: verbatim copying and redistribution of this article are permitted in all media for any non-commercial purpose, provided this notice is preserved along with the articles original URL. Abstract Background: Members of a class of bHLH transcription factors, namely the hairy (h), Enhancer of split (E(spl)) and hairy-related with YRPW motif (hey) (h/E(spl)/hey) genes are involved in vertebrate somitogenesis and some of them show cycling expression. By sequence comparison, identified orthologues of cycling somitogenesis genes from higher vertebrates do not show an appropriate expression pattern in zebrafish. The zebrafish genomic sequence is not available yet but the genome of Fugu rubripes was recently published. To allow comparative analysis, the currently known Her proteins from zebrafish were used to screen the genomic sequence database of Fugu rubripes. Results: 20 h/E(spl)/hey-related genes were identified in Fugu, which is twice the number of corresponding zebrafish genes known so far. A novel class of c-Hairy proteins was identified in the genomes of Fugu and Tetraodon. A screen of the human genome database with the Fugu proteins yielded 10 h/E(spl)/hey-related genes. By analysing the upstream sequences of the c-hairy class genes in zebrafish, Fugu a