Comparative analysis of the kinomes of three pathogenic trypanosomatids Leishmania major, Trypanosoma brucei and Trypanosoma cruzi.docVIP

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Comparative analysis of the kinomes of three pathogenic trypanosomatids Leishmania major, Trypanosoma brucei and Trypanosoma cruzi.doc

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Comparative analysis of the kinomes of three pathogenic trypanosomatids Leishmania major, Trypanosoma brucei and Trypanosoma cruzi

BMC Genomics BioMedCentral Research article Open Access Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and Trypanosoma cruzi Marilyn Parsons*1,2, Elizabeth A Worthey1, Pauline N Ward3 and Jeremy C Mottram3 Address: 1Seattle Biomedical Research Institute, 307 Westlake Ave. N., Seattle, WA, 98109 USA, 2Department of Pathobiology, University of Washington, Seattle, WA, 98195 USA and 3Wellcome Centre for Molecular Parasitology, The Anderson College, University of Glasgow, Glasgow G11 6NU, UK Email: Marilyn Parsons* - marilyn.parsons@; Elizabeth A Worthey - Elizabeth_Worthey@; Pauline N Ward - pauline.ward@bbsrc.ac.uk; Jeremy C Mottram - j.mottram@bio.gla.ac.uk * Corresponding author Published: 15 September 2005 Received: 15 July 2005 Accepted: 15 September 2005 BMC Genomics 2005, 6:127 doi:10.1186/1471-2164-6-127 This article is available from: /1471-2164/6/127 ? 2005 Parsons et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The trypanosomatids Leishmania major, Trypanosoma brucei and Trypanosoma cruzi cause some of the most debilitating diseases of humankind: cutaneous leishmaniasis, African sleeping sickness, and Chagas disease. These protozoa possess complex life cycles that involve development in mammalian and insect hosts, and a tightly coordinated cell cycle ensures propagation of the highly polarized cells. However, the ways in which the parasites respond to their environment and coordinate intracellular processes are poorly understood. As a part of an effort to understand parasite signaling functions, we report the results of a genome-wide analysis of protein kinases (PKs) of these three tr