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Comparative analysis between a low pathogenic and a high pathogenic influenza H5 hemagglutinin in cell entry.doc

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Comparative analysis between a low pathogenic and a high pathogenic influenza H5 hemagglutinin in cell entry

Virology Journal BioMedCentral Short report Open Access Comparative analysis between a low pathogenic and a high pathogenic influenza H5 hemagglutinin in cell entry Emily Rumschlag-Booms1, Ying Guo1,2, Jizhen Wang1, Michael Caffrey3 and Lijun Rong*1 Address: 1Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA, 2Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, PR China and 3Department of Biochemistry and Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607, USA Email: Emily Rumschlag-Booms - emily.rumschlag@; Ying Guo - yingguo6@; Jizhen Wang - jwang27@; Michael Caffrey - caffrey@; Lijun Rong* - lijun@ * Corresponding author Published: 10 June 2009 Received: 29 April 2009 Accepted: 10 June 2009 Virology Journal 2009, 6:76 doi:10.1186/1743-422X-6-76 This article is available from: /content/6/1/76 ? 2009 Rumschlag-Booms et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Avian influenza viruses continue to threaten globally with pandemic potential. The first step in a potential pandemic is the ability of the virus to enter human cells which is mediated by the viral surface glycoprotein hemagglutinin (HA). Viral entry of influenza is dependent upon the processing of the HA polypeptide precursor protein into HA and HA which is mediated by host cellular 0 1 2 proteases. The sequence of the cleavage site which is recognized by host proteases has been linked with pathogenesis of various influenza viruses. Here we examined the effects of cleavage site sequences between a highly pathogenic H5N1