Dual activation of pathways regulated by steroid receptors and peptide growth factors in primary prostate cancer revealed by Factor Analysis of microarray data.docVIP

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Dual activation of pathways regulated by steroid receptors and peptide growth factors in primary prostate cancer revealed by Factor Analysis of microarray data.doc

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Dual activation of pathways regulated by steroid receptors and peptide growth factors in primary prostate cancer revealed by Factor Analysis of microarray data

BMC Genomics BioMedCentral Research article Open Access Dual activation of pathways regulated by steroid receptors and peptide growth factors in primary prostate cancer revealed by Factor Analysis of microarray data Juan Jose Lozano1,2,5, Marta Soler3, Raquel Bermudo3, David Abia1, Pedro L Fernandez4, Timothy M Thomson*3 and Angel R Ortiz*1,2 Address: 1Bioinformatics Unit, Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain, 2Department of Physiology and Biophysics, Mount Sinai School of Medicine, One Gustave Levy Pl., New York, NY 10029, USA, 3Instituto de Biología Molecular, Consejo Superior de Investigaciones Científicas, c. Jordi Girona 18–26, 08034 Barcelona, Spain, 4Departament de Anatomía Patològica, Hospital Clínic, and Institut de Investigacions Biomèdiques August Pi i Sunyer, c. Villarroel 170, 08036 Barcelona, Spain and 5Center for Genome Regulation, Barcelona (Spain) Email: Juan Jose Lozano - juanjo.lozano@crg.es; Marta Soler - msobmc@cid.csic.es; Raquel Bermudo - rbebmc@cid.csic.es; David Abia - dabia@cbm.uam.es; Pedro L Fernandez - plfernan@clinic.ub.es; Timothy M Thomson* - ttobmc@cid.csic.es; Angel R Ortiz* - aro@cbm.uam.es * Corresponding authors Published: 17 August 2005 Received: 17 January 2005 Accepted: 17 August 2005 BMC Genomics 2005, 6:109 doi:10.1186/1471-2164-6-109 This article is available from: /1471-2164/6/109 ? 2005 Lozano et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: We use an approach based on Factor Analysis to analyze datasets generated for transcriptional profiling. The method groups samples into biologically relevant categories, and enables the identification of genes and path