Early postoperative therapy after heart transplantation Prophylaxis, diagnosis and antibiotic, antimycotic and antiviral therapy of infections.docVIP
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Early postoperative therapy after heart transplantation Prophylaxis, diagnosis and antibiotic, antimycotic and antiviral therapy of infections
190
Transplantationsmedizin
2011, 23. Jahrgang
M. Hummel
Early Postoperative Therapy after Heart Transplantation
Early Postoperative Therapy after Heart
Transplantation: Prophylaxis, Diagnosis and
Antibiotic, Antimycotic and Antiviral Therapy of
Infections
Manfred Hummel
Paulinenkrankenhaus, Berlin, Germany
Aside from early graft failure,infections are the second leading cause of death after heart transplan-
tation (HTx).Therefore, prophylaxis, diagnosis and adequate therapy of infections are fundamental
for the short and long-term success of heart transplantation. Because immunosuppressive drug
therapy is a prerequisite for transplantation, the range of infection is much larger than after other
kinds of major thoracic operation.For prophylaxis,diagnosis and therapy,bacterial, viral,fungal and
protozoal infections have to be taken into account, also as part of opportunistic infection.So far ev-
idence-based recommendations for the prophylaxis and therapy of infections after HTx are rare.
Therefore, it is necessary to use clinically proven strategies to prevent and treat infections.
Key words: heart transplantation, infection, immunosuppression
Frühe postoperative Therapie nach Herztransplantation:
Prophylaxe, Diagnose und antibiotische, antimykotische und antivirale Therapie von
Infektionen
Neben dem frühen Transplantatversagen stellen Infektionen die zweith?ufigste Todesursache nach
Herztransplantation (HTx) dar.Die Prophylaxe,Diagnose und richtige Therapie von Infektionen sind
daher von grundlegender Bedeutung für den kurz- und langfristigen Erfolg einer Herztransplanta-
tion. Die immunsuppressive Behandlung ist eine Grundvoraussetzung für die Transplantation. Da-
her muss mit einer deutlich h?heren Rate an Infektionen gerechnet werden, als bei vergleichbaren
gro?en thorakalen Operationen. Bei der Prophylaxe, Diagnose und Therapie müssen neben ambu-
lant oder nosokomial erworbenen bakteriellen, viralen Pilz- und Protozoeninfektionen auch oppor-
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