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Eccrine porocarcinoma of the lower extremity A case report and review of literature.doc

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Eccrine porocarcinoma of the lower extremity A case report and review of literature

Changetal.WorldJournalofSurgicalOncology2011,9:94 /content/9/1/94 WORLD JOURNAL OF SURGICAL ONCOLOGY CASE REPORT OpenAccess Eccrineporocarcinomaofthelowerextremity: Acasereportandreviewofliterature OliverChang ,AshrafElnawawi ,BernardRimpel ,ArmandAsarian andNadeemChaudhry5 1* 2 3 4 Abstract Eccrineporocarcinomaisararemalignancyoftheeccrinesweatgland.Itisusuallyfoundfrequentlyonthelower extremities,anditaffectsbothsexesequallyusuallyinthesixthtoseventhdecade.Inourcase,wepresenta42- year-oldmalepatientwitharecurringexophytictumorontherightlowerextremitywithoutlocalextension.The initialtumorwasbiopsied,excisedanddiagnosedasaneccrineporoma.Thetumorthenrecurred6yearslater, wasre-excised,reconstructedwithasoleusmuscleflapanddiagnosedasaneccrineporocarcinoma. Keywords:eccrineporocarcinoma,sweatglandtumor,malignanteccrineporoma Background Onphysicalexam,therewerenolymphadenopathyin Eccrine porocarcinoma (EPC), arare malignant sweat theinguinal,axillaryorclavicularareaswerenoted.The glandtumor,representingonly0.005%ofepithelialcuta- tumoritselfmeasured3.0×2.0cmwithawidthof0.6cm neous neoplasms. Thefirst reported case, in1963, was (Figure1).Pinkexophytic,fungatingoutgrowthsareasig- attributedtoPinkusandMehregan[1],coinedas“epider- naturetothistumor.Incombination withthepatient’s motropiceccrinecarcinoma”,andsincethen,presentation previous history of benign poroma, the treatment of havebeenlimitedduetotherarityofthistumor.Itwas choicewasawidelocalexcisionofthemasswith2.5cm onlyafewyearslater,theterm“eccrineporocarcinoma” margins-bothcircumferentiallyanddeeptothelevelof was introduced by Mishma and Morioka in 1969 [2]. theperiosteum.Asoleusmuscleflapwasthenraisedand These lesions are most commonly found onthe lower usedtoreconstructthedefect.Themusclewasthencov- extremities,followedbythehead,scalp,upperextremities, eredwithasplitthicknessskingraft. trunkandabdomen[1,3-11]. Thetumorcanarisefrom Themacroscopicexaminationofthespecimenshowed