Dysgerminoma in three patients with Swyer syndrome.docVIP

World Journal of Surgical Oncology BioMedCentral Review Open Access Dysgerminoma in three patients with Swyer syndrome Nadereh Behtash* and Mojgan Karimi Zarchi Address: Gynecology Oncology Department, Vali-Asr Hospital, Keshavarz Blvd., Tehran 14194, Iran Email: Nadereh Behtash* - nadbehtash@; Mojgan Karimi Zarchi - drkarimi2001@ * Corresponding author Published: 23 June 2007 Received: 2 January 2007 Accepted: 23 June 2007 World Journal of Surgical Oncology 2007, 5:71 doi:10.1186/1477-7819-5-71 This article is available from: /content/5/1/71 ? 2007 Behtash and Karimi Zarchi; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Dysgerminoma is the most common malignant germ cell tumor of the ovary. This malignancy can be associated with pure gonadal dysgenesis or Swyer syndrome, mixed gonadal dysgenesis and partial gonadal dysgenesis. Case presentation: Dysgerminoma developed in 3 phenotypic female patients with 46 XY pure gonadal dysgenesis. All patients presented first with abdominopelvic mass. Laparatomy was done. 46 XY karyotype was made by lymphocyte culture. Then these patients underwent gonadectomy that histopathology results were streak ovaries without evidence for malignancy. Two patients received postoperative adjuvant therapy. Conclusion: In Patients with Swyer syndrome the risk of dysgerminoma is high and gonadectomy is recommended. Also 5% of dysgerminomas are discovered in phenotypic female and 46 XY karyotype, thus in adolescent with dysgerminoimas and amenorrhea, karyotype should be done. Background secondary amenorrhea. All the patients had dysgermi- noma, that underwent unilateral salpingoopherectomy and two of these, received adjuvant