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Effect of influenza and pneumococcal vaccines in elderly persons in years of low influenza activity.doc

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Effect of influenza and pneumococcal vaccines in elderly persons in years of low influenza activity

Virology Journal BioMedCentral Research Open Access Effect of influenza and pneumococcal vaccines in elderly persons in years of low influenza activity Brith Christenson1, Karlis Pauksen2 and Staffan PE Sylvan*1 Address: 1Department of Communicable Disease Control and prevention, Uppsala County Counci, Dag Hammarskjolds vag 17, SE-751-85 Uppsala, Sweden and 2Department of Medical sciences, Infectious Diseases, Uppsala University Hospital Uppsala, Sweden Email: Brith Christenson - brith.christensson@lul.se; Karlis Pauksen - karlis.pauksen@akademiska.se; Staffan PE Sylvan* - staffan.sylvan@lul.se * Corresponding author Published: 28 April 2008 Received: 14 February 2008 Accepted: 28 April 2008 Virology Journal 2008, 5:52 doi:10.1186/1743-422X-5-52 This article is available from: /content/5/1/52 ? 2008 Christenson et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The present prospective study was conducted from 2003–2005, among all individuals 65 years and older in Uppsala County, a region with 300 000 inhabitants situated close to the Stockholm urban area. The objective of this study was to assess the preventive effect of influenza and pneumococcal vaccination in reducing hospitalisation and length of hospital stay (LOHS) even during periods of low influenza activity. The specificity of the apparent vaccine associations were evaluated in relation to the influenza seasons. Results: In 2003, the total study population was 41,059, of which 12,907 (31%) received influenza vaccine of these, 4,447 (11%) were administered the pneumococcal vaccine. In 2004, 14,799 (34%) individuals received the influenza vaccine and 8,843 (21%) the pneumococcal vaccine and in 2005 16,926