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Vol.4, No.12, 1295-1298 (2012) Health /10.4236/health.2012.412190 Effective treatment of resistant Escherichia coli infection, with sulphadimidine stabilized in a synthetic Aluminium-Magnesium Silicate Maduike C. O. Ezeibe , Uchenna M. Chima , Augustine A. Ngene , Obianuju N. Okoroafor , 1* 1 1 1 1 2 Idika I. Kalu , Mfon E. Esen 1 * 2 Department of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria; Corresponding Author: maduikeezeibe@ Department of Veterinary Parasitology and Entomology, University of Nigeria, Nsukka, Nigeria Received 23 September 2012; revised 23 October 2012; accepted 5 November 2012 ABSTRACT against drugs and among bacteria, Escherichia coli is often involved in drug resistance [2]. To investigate if Aluminium-Magnesium Silicate (AMS) could make drugs regain effects against resistant pathogens, its effect was tested on sul- phadimidine against sulphadimidine-resistant Escherichia coli. Two groups of chicks infected with sulphadimidine-resistant E. coli were trea- ted at sulphadimidine dose rate of 1 g/litre of drinking water, with sulphadimidine and with an AMS-sulphadimidine drug formulation, respec- tively. Two other groups were similarly treated at sulphadimidine dose rate of 0.75 g/litre, while the fifth group served as control. Mean titres of the bacterium in bile of the chicks were com- pared. Titres, 119,200 ± 55,800 CFU/mL of the group treated with sulphadimidine at rate of 1 g/ litre and 14,800 ± 1700 CFU/mL of the group treated at rate of 0.75 g/litre, did not vary from 33,200 ± 5200 CFU/mL of the control (P 0.05) but 295,200 ± 106,400 CFU/ml of the group treated at rate of 1 g/litre, with the AMS-sulpha- dimidine drug was significantly (P 0.05) higher than that of th