Anthocyanin-Rich Juice Lowers Serum Cholesterol, Leptin, and Resistin and Improves Plasma Fatty Acid Composition in Fischer Rats.docVIP

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Anthocyanin-Rich Juice Lowers Serum Cholesterol, Leptin, and Resistin and Improves Plasma Fatty Acid Composition in Fischer Rats.doc

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Anthocyanin-Rich Juice Lowers Serum Cholesterol, Leptin, and Resistin and Improves Plasma Fatty Acid Composition in Fischer Rats

Anthocyanin-RichJuiceLowersSerumCholesterol, Leptin,andResistinandImprovesPlasmaFattyAcid CompositioninFischerRats DanielaGraf,StephanieSeifert,AnkeJaudszus,AchimBub,BernhardWatzl* DepartmentofPhysiologyandBiochemistryofNutrition,MaxRubner-Institut,FederalResearchInstituteofNutritionandFood,Karlsruhe,Germany Abstract Obesity and obesity-associated diseases e.g. cardiovascular diseases and type 2 diabetes are spread worldwide. Anthocyaninsaresupposedtohavehealth-promotingproperties,althoughconvincingevidenceislacking.Theaimofthe presentstudywastoinvestigatetheeffectofanthocyaninsonseveralriskfactorsforobesity-associateddiseases.Therefore, Fischer rats were fed anthocyanin-rich grape-bilberry juice or an anthocyanin-depleted control juice for 10 weeks. Intervention with anthocyanin-rich grape-bilberry juice reduced serum cholesterol and tended to decrease serum triglycerides.Noeffectswereseenforserumnon-esterifiedfattyacids,glucose,andinsulin.Anthocyanin-richgrape-bilberry juice intervention reduced serum leptin and resistin, but showed no influence on serum adiponectin and secretion of adipokinesfrommesentericadiposetissue.Furthermore,anthocyanin-richgrape-bilberryjuiceincreasedtheproportionof polyunsaturated fatty acids and decreased the amount of saturated fatty acids in plasma. These results indicate that anthocyaninspossessapreventivepotentialforobesity-associateddiseases. Citation:GrafD,SeifertS,JaudszusA,BubA,WatzlB(2013)Anthocyanin-RichJuiceLowersSerumCholesterol,Leptin,andResistinandImprovesPlasmaFatty AcidCompositioninFischerRats.PLoSONE8(6):e66690.doi:10.1371/journal.pone.0066690 Editor:SilvanaGaetani,SapienzaUniversityofRome,Italy ReceivedFebruary1,2013;AcceptedMay8,2013;PublishedJune18,2013 Copyright:?2013Grafetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted use,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:Thisstudyhasbeenfinanciallysu