Antidiabetic, Antihyperlipidemic and Antioxidant Activities of a Novel Proteoglycan from Ganoderma Lucidum Fruiting Bodies on dbdb Mice and the Possible Mechanism.docVIP

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Antidiabetic, Antihyperlipidemic and Antioxidant Activities of a Novel Proteoglycan from Ganoderma Lucidum Fruiting Bodies on dbdb Mice and the Possible Mechanism.doc

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Antidiabetic, Antihyperlipidemic and Antioxidant Activities of a Novel Proteoglycan from Ganoderma Lucidum Fruiting Bodies on dbdb Mice and the Possible Mechanism

Antidiabetic,AntihyperlipidemicandAntioxidant ActivitiesofaNovelProteoglycanfromGanoderma LucidumFruitingBodiesondb/dbMiceandthePossible Mechanism DengPan1,DangZhang2,JiashengWu3,ConghengChen1,ZhixueXu1,HongjieYang2*,PingZhou1* 1State KeyLaboratory of Molecular Engineering ofPolymers,Department of Macromolecular Science, Fudan University,Shanghai,P. R. China, 2YueyangHospital of IntegratedTraditionalChineseandWesternMedicine,ShanghaiUniversityofTraditionalChineseMedicine,Shanghai,P.R.China,3PharmacyCollege,ShanghaiUniversity ofTraditionalChineseMedicine,Shanghai,P.R.China Abstract Previously,wescreenedaproteoglycanforanti-hyperglycemic,namedFYGL,fromGanodermaLucidum.Forfurtherresearch of the antidiabetic mechanisms of FYGL in vivo, the glucose homeostasis, activities of insulin-sensitive enzymes, glucose transporterexpressionandpancreaticfunctionwereanalyzedusingdb/dbmiceasdiabeticmodelsinthepresentwork. FYGLnotonlyleadtoareductioninglycatedhemoglobinlevel,butalsoanincreaseininsulinandC-peptidelevel,whereas a decrease in glucagons level and showed a potential for the remediation of pancreatic islets. FYGL also increased the glucokinaseactivities,andsimultaneouslyloweredthephosphoenolpyruvatecarboxykinaseactivities,accompaniedbya reductionintheexpressionofhepaticglucosetransporterprotein2,whiletheexpressionofadiposeandskeletalglucose transporterprotein4wasincreased.Moreover,theantioxidantenzymeactivitieswerealsoincreasedbyFYGLtreatment. Thus,FYGLwasaneffectiveantidiabeticagentbyenhancinginsulinsecretionanddecreasinghepaticglucoseoutputalong withincreaseofadiposeandskeletalmuscleglucosedisposalinthelatestageofdiabetes.Furthermore,FYGLisbeneficial againstoxidativestress,therebybeinghelpfulinpreventingthediabeticcomplications. Citation:PanD,ZhangD,WuJ,ChenC,XuZ,etal.(2013)Antidiabetic,AntihyperlipidemicandAntioxidantActivitiesofaNovelProteoglycanfromGanoderma LucidumFruitingBodiesondb/dbMiceandthePossibleMechanism.PLoSONE8(7):e68332.doi:10.1371/journal.pone.0068332 Ed