Application of bromate-bromide mixture as a green brominating agent for the spectrophotometric determination of atenolol in pharmaceuticals.docVIP

下载本文档

1
0
约 10页
2017-05-07 发布于上海
举报
版权申诉

Application of bromate-bromide mixture as a green brominating agent for the spectrophotometric determination of atenolol in pharmaceuticals.doc

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Application of bromate-bromide mixture as a green brominating agent for the spectrophotometric determination of atenolol in pharmaceuticals

Available on line at Association of the Chemical Engineers of Serbia AChE .rs/CICEQ Chemical Industry Chemical Engineering Quarterly 18 (1) 43?52 (2012) CICEQ APPLICATION OF BROMATE–BROMIDE MIXTURE AS A GREEN BROMINATING AGENT FOR THE SPECTROPHOTOMETRIC DETERMINATION OF ATENOLOL IN PHARMACEUTICALS KUDIGE NAGARAJ PRASHANTH KANAKAPURA BASAVAIAH SAMEER A. M. ABDULRAHMAN NAGARAJU RAJENDRAPRASAD KANAKAPURA BASAVAIAH VINAY Two highly sensitive spectrophotometric methods are proposed for the quanti- fication of atenolol (ATN) in pure drug as well as in pharmaceutical formula- tions. The methods are based on the bromination reaction of ATN with a known excess of bromate-bromide mixture in acid medium followed by the determi- nation of unreacted bromine. The residual bromine is determined by its reac- tion with excess iodide and the liberated iodine (I3 ) is either measured at 360 nm (method A) or reacted with starch followed by the measurement of the starch-iodine chromogen at 570 nm (method B). Under the optimum condi- tions, ATN could be assayed in the concentration ranges of 0.5-9.0 and 0.3-6.0 μg mL-1 for methods A and B, respectively, with corresponding molar absorpti- vity values of 2.36?104 and 2.89?104 L mol-1 cm-1. Sandell’s sensitivity values are found to be 0.0113 and 0.0092 μg/cm2 for methods A and B, respectively. The proposed methods were successfully applied to the analysis of different commercial brands of pharmaceutical formulations and the results obtained by the proposed methods were in good agreement with those obtained using the reference method. The reliability of the methods was further ascertained by recovery studies using standard- addition method. Department of Chemistry, University of Mysore, Manasagangotri, Mysore, Karnataka, India SCIENTIFIC PAPER UDC 615.22:661.12 DOI 10.2298/CICEQ110721045P Keywords: atenolol, assay; bromate-bromide mixture; spectrophoto- metry; pharmaceu