Apolipoprotein E Gene Variants on the Risk of End Stage Renal Disease.docVIP

Apolipoprotein E Gene Variants on the Risk of End Stage Renal Disease Cheng Xue1?, Wei Nie2?, Dan Tang3?, Lujiang Yi4?, Changlin Mei1* 1 Department of Nephrology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China, 2 Department of Respiratory Disease, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China, 3 Department of Gastroenterology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China, 4 Department of Clinical Laboratory, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China Abstract Objective: End-stage renal disease (ESRD) is a severe health concern over the world. Associations between apolipoprotein E (apoE) gene polymorphisms and the risk of ESRD remained inconclusive. This study aimed to investigate the association between apoE gene polymorphisms and ESRD susceptibility. Methods: Databases including PubMed, Embase, Web of Science and the Cochrane Library were searched to find relevant studies. Meta-analysis method was used synthesize the eligible studies. Results: Sixteen pertinent case-control studies which included 3510 cases and 13924 controls were analyzed. A signi?cant association was found between ε2 allele and the ESRD risk (odds ratio (OR) = 1.30, 95% con?dence 2 interval (CI) 1.15–1.46, P 0.0001; I = 18%, P for heterogeneity = 0.24). The ε2ε3, ε2ε4, ε3ε3, ε3ε4, ε4ε4, ε3 and ε4 were not associated with the susceptibility of ESRD. In the subgroup analysis by ethnicity, there was a statistically significant association between ε2ε3 or ε2 allele and ESRD risk in East Asians (OR = 1.66, 95% CI 1.31–2.10, P 0.0001; OR = 1.62, 95% CI 1.31–2.01, P 0.0001, respectively), but not in Caucasians. E2 carriers had higher plasma apoE (mean difference = 16.24 mg/L, 95% CI 7.76-24.73, P = 0.0002) than the (ε3 + ε4) carriers in patients wit