Asymmetric Reductive Amination of Carbonyl Compounds by Using.docVIP

International Journal of Organic Chemistry, 2013, 3, 190-193 /10.4236/ijoc.2013.33024 Published Online September 2013 (/journal/ijoc) Asymmetric Reductive Amination of Carbonyl Compounds by Using N,N,N-Tributylpropanaminium Based Novel Chiral Ionic Liquid Boyina Rupini , Sharda Pasricha , Brijesh Rathi 1* 2 2* School of Agriculture, Environmental Studies, Indira Gandhi National Open University, New Delhi, India Department of Chemistry, Sri Venkateswara College, University of Delhi, New Delhi, India Email: brupini@ignou.ac.in * 1 2 Received July 6, 2013; revised August 7, 2013; accepted August 15, 2013 Copyright ? 2013 Boyina Rupini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ABSTRACT Asymmetric reductive amination of carbonyl compounds was carried out using a novel class of aliphatic quarternary ammonium based chiral ionic liquid. S-(+)-2,3-dihydroxy-N,N,N-tributylpropanaminum bromide chiral ionic liquid has been synthesized, characterized and used for asymmetric reductive amination of carbonyl compounds in the presence of sodium borohydride. These preliminary results are encouraging and advocate dual role of novel ionic liquid as a me- dium and reducing agent for proficient conversion of ketones to amines, however, reductive amination reaction needs to be established for other substituents. Keywords: Ionic Liquid; Asymmetric Reductive Amination; Chiral; Carbonyl Compounds 1. Introduction recycling. Also ionic liquids have been used as an alter- native reaction media for several reactions [14,15] in- cluding electrolytes for batteries [16]. Among the room temperature ionic liquids, chiral ionic liquids are known to be attractive and important for their potential ap