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Attention Enhances the Retrieval and Stability of Visuospatial and Olfactory Representations in the Dorsal Hippocampus.doc

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Attention Enhances the Retrieval and Stability of Visuospatial and Olfactory Representations in the Dorsal Hippocampus

AttentionEnhancestheRetrievalandStabilityof VisuospatialandOlfactoryRepresentationsintheDorsal Hippocampus IsabelA.Muzzio1¤a,LiatLevita1¤b,JayantKulkarni1,JosephMonaco1,CliffordKentros2 ,Matthew Stead3,LarryF.Abbott1,EricR.Kandel1,4* 1Department of Neuroscience, Columbia University, College of Physicians and Surgeons, New York, New York, United States of America, 2Psychology Department, University of Oregon, Eugene, Oregon, United States of America, 3Mayo Clinic, Rochester, Minnesota, United States of America, 4Howard Hughes Medical Institute, ColumbiaUniversity,NewYork,NewYork,UnitedStatesofAmerica Abstract Akeyquestionintheanalysisofhippocampalmemoryrelatestohowattentionmodulatestheencodingandlong-term retrievalofspatialandnonspatialrepresentationsinthisregion.Toaddressthisquestion,werecordedfromsinglecellsover aperiodof5daysintheCA1regionofthedorsalhippocampuswhilemiceacquiredoneoftwogoal-orientedtasks.These tasksrequiredtheanimalstofindahiddenfoodrewardbyattendingtoeitherthevisuospatialenvironmentoraparticular odorpresentedinshiftingspatiallocations.Attentiontothevisuospatialenvironmentincreasedthestabilityofvisuospatial representations and phase locking to gamma oscillations—a form of neuronal synchronization thought to underlie the attentional mechanism necessary for processing task-relevant information. Attention to a spatially shifting olfactory cue compromisedthestabilityofplacefieldsandincreasedthestabilityofreward-associatedodorrepresentations,whichwere most consistently retrieved during periods of sniffing and digging when animals were restricted to the cup locations. Together, these results suggest that attention selectively modulates the encoding and retrieval of hippocampal representationsbyenhancingphysiologicalresponsestotask-relevantinformation. Citation: Muzzio IA, Levita L, Kulkarni J, Monaco J, Kentros C, et al. (2009) Attention Enhances the Retrieval and Stability of Visuospatial and Olfactory RepresentationsintheDorsalHippocampus.PLoSBiol7(