B7-H3 is Overexpressed in Patients Suffering Osteosarcoma and Associated with Tumor Aggressiveness and Metastasis.docVIP

下载本文档

4
0
约3.86万字
约 8页
2017-05-07 发布于上海
举报
版权申诉

B7-H3 is Overexpressed in Patients Suffering Osteosarcoma and Associated with Tumor Aggressiveness and Metastasis.doc

1、本文档共8页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

B7-H3 is Overexpressed in Patients Suffering Osteosarcoma and Associated with Tumor Aggressiveness and Metastasis

B7-H3isOverexpressedinPatientsSuffering OsteosarcomaandAssociatedwithTumor AggressivenessandMetastasis LingWang1,2.,QiZhang1,3.,WeiChen1,3.,BaoenShan2,YangDing4,GuochuanZhang5,NanaCao2, LeiLiu3,YingzeZhang1,3* 1HebeiBoneResearchInstitute,ThirdHospitalofHebeiMedicalUniversity,Shijiazhuang,Hebei,P.R.China,2HebeiCancerResearchInstitute,FourthHospitalofHebei Medical University, Shijiazhuang, Hebei, P.R. China, 3Department ofOrthopaedic Surgery, Third Hospital ofHebei Medical University, Shijiazhuang, Hebei, P.R. China, 4DepartmentofPathology,ThirdHospitalofHebeiMedicalUniversity,Shijiazhuang,Hebei,P.R.China,5DepartmentofOrthopedicOncology,ThirdHospitalofHebei MedicalUniversity,Shijiazhuang,Hebei,P.R.China Abstract B7-H3isamemberoftheB7-familyofco-stimulatorymolecules,whichhasbeenshowntobebroadlyexpressedinvarious tumor tissues, and which plays an important role in adaptive immune responses. The role of B7-H3 in osteosarcoma, however, remains unknown. In this study we used immunohistochemistry to analyze B7-H3 expression in 61 primary osteosarcomatissueswithcase-matchedadjacentnormaltissues,and37osteochondromaand20bonefibrousdysplasia tissues.B7-H3expressionwasexpressedin91.8%(56/61)oftheosteosarcomalesions,andtheintensityofB7-H3expression in osteosarcoma was significantly increased compared with adjacent normal tissues, osteochondroma and bone fibrous dysplasiatissues(p,0.001).PatientswithhightumorB7-H3levelshadasignificantlyshortersurvivaltimeandrecurrence timethanpatientswithlowtumorB7-H3levels(p,0.001).Moreover,tumorB7-H3expressioninverselycorrelatedwiththe + number of tumor-infiltrating CD8 T cells (p,0.05). In vitro, increasing expression of B7-H3 promotes osteosarcoma cell invasion, at least in part by upregulating matrixmetalloproteinase-2 (MMP-2). Inconclusion, our study provides thefirst evidence of B7-H3 expression in osteosarcoma cells as a potential mechanism controlling tumor immunity and invasive malignancy,andwhichiscorrelatedwithpatients’survivalandmet