Tracing the origins and signatures of selection of antifolate resistance in island populations of Plasmodium falciparum 英文论文文献.docVIP

Salgueiro et al. BMC Infectious Diseases 2010, 10:163 /1471-2334/10/163 RESEARCH ARTICLE Open Access Tracing the origins and signatures of selection of Research article antifolate resistance in island populations of Plasmodium falciparum Patrícia Salgueiro1, José L Vicente1, Concei??o Ferreira2, Vania Teófilo1, André Galv?o1, Virgílio E do Rosário1, Pedro Cravo1 and Jo?o Pinto*1 Abstract Background: Resistance of the malaria parasite Plasmodium falciparum to sulfadoxine-pyrimethamine (SP) has evolved worldwide. In the archipelago of S?o Tomé and Principe (STP), West Africa, although S