原创力文档UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation 英文论文文献.docVIP
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UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation 英文论文文献
Bandauetal.BMCBiology2012,10:36
/1741-7007/10/36
RESEARCH ARTICLE
OpenAccess
UBXN7docksonneddylatedcullincomplexes
usingitsUIMmotifandcausesHIF1a
accumulation
SusanneBandau1,AxelKnebel1,ZoeOGage1,2,NicolaTWood1andGabrielaAlexandru1*
Abstract
Background:TheproteinsfromtheUBA-UBXfamilyinteractwithubiquitylatedproteinsviatheirUBAdomainand
withp97viatheirUBXdomain,therebyactingassubstrate-bindingadaptorsforthep97ATPase.Inparticular,
humanUBXN7(alsoknownasUBXD7)mediatesp97interactionwiththetranscriptionfactorHIF1athatisactively
ubiquitylatedinnormoxiccellsbyaCUL2-basedE3ligase,CRL2.Massspectrome
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