Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole failure of its therapeutic activity against triclabendazole-resistant liver flukes 英文论文文献.docVIP

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Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole failure of its therapeutic activity against triclabendazole-resistant liver flukes 英文论文文献.doc

Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole failure of its therapeutic activity against triclabendazole-resistant liver flukes 英文论文文献

Ceballosetal.BMCVeterinaryResearch2010,6:8 /1746-6148/6/8 RESEARCH ARTICLE OpenAccess Unchangedtriclabendazolekineticsafterco- administrationwithivermectinandmethimazole: failureofitstherapeuticactivityagainst triclabendazole-resistantliverflukes LauraCeballos1,2?,LauraMoreno1,2?,LuisAlvarez1,2,LauraShaw3,IanFairweather3,CarlosLanusse1,2* Abstract Background:Thereduceddrugaccumulationbasedonenhanceddrugeffluxandmetaboliccapacity,identifiedin triclabendazole(TCBZ)-resistantFasciolahepaticamaycontributetothedevelopmentofresistancetoTCBZ.The aimofthisworkwastoevaluatethepharmacokineticsandclin

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Unchanged triclabendazole kinetics after co-administration with ivermectin and methimazole failure of its therapeutic activity against triclabendazole-resistant liver flukes 英文论文文献.docVIP