Using mouse models to study function of transcriptional factors in T cell development 英文论文文献.docVIP

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Using mouse models to study function of transcriptional factors in T cell development 英文论文文献.doc

Using mouse models to study function of transcriptional factors in T cell development 英文论文文献

Lietal.CellRegeneration2012,1:8 /content/1/1/8 REVIEW OpenAccess Usingmousemodelstostudyfunctionof transcriptionalfactorsinTcelldevelopment PengLi1,2*,YirenXiao1,2,ZhixinLiu1,2*andPentaoLiu3 Abstract Laboratorymicehavewidelybeenusedastoolsforbasicbiologicalresearchandmodelsforstudyinghuman diseases.Withtheadvancesofgeneticengineeringandconditionalknockout(CKO)mice,wenowunderstand hematopoiesisisadynamicstepwiseprocessstartingfromhematopoieticstemcells(HSCs)whichareresponsible forreplenishingallbloodcells.Transcriptionalfactorsplayimportantroleinhematopoiesis.Inthisreviewwe compileseveralstud

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