Validation of dot blot hybridization and denaturing high performance liquid chromatography as reliable methods for TP53 codon 72 genotyping in molecular epidemiologic studies 英文论文文献.docVIP

Rabachini et al. BMC Genetics 2010, 11:44 /1471-2156/11/44 METHODOLOGY ARTICLE Open Access Validation of dot blot hybridization and denaturing Methodology article high performance liquid chromatography as reliable methods for TP53 codon 72 genotyping in molecular epidemiologic studies Tatiana Rabachini1,2,3,4, Helen Trottier5,6, Eduardo L Franco5 and Luisa L Villa*1,2 Abstract Background: Mutations in TP53 are common events during carcinogenesis. In addition to gene mutations, several reports have focused on TP53 polymorphisms as risk factors for malignant disease. Many studies have