Visualisation of variable binding pockets on protein surfaces by probabilistic analysis of related structure sets 英文论文文献.docVIP

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Visualisation of variable binding pockets on protein surfaces by probabilistic analysis of related structure sets 英文论文文献.doc

Visualisation of variable binding pockets on protein surfaces by probabilistic analysis of related structure sets 英文论文文献

Ashfordetal.BMCBioinformatics2012,13:39 /1471-2105/13/39 METHODOLOGY ARTICLE OpenAccess Visualisationofvariablebindingpocketson proteinsurfacesbyprobabilisticanalysisof relatedstructuresets PaulAshford1,DavidSMoss1,AlexanderAlex2,SiewKYeap2,AlicePovia1,IreneNobeli1* andMarkAWilliams1* Abstract Background:Proteinstructuresprovideavaluableresourceforrationaldrugdesign.Foraproteinwithnoknownligand, computationaltoolscanpredictsurfacepocketsthatareofsuitablesizeandshapetoaccommodateacomplementary small-moleculedrug.However,pocketpredictionagainstsinglestaticstructuresmaymissfeaturesofpoc

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Visualisation of variable binding pockets on protein surfaces by probabilistic analysis of related structure sets 英文论文文献.docVIP