Visualisation of variable binding pockets on protein surfaces by probabilistic analysis of related structure sets 英文论文文献.docVIP

  • 5
  • 0
  • 约6.24万字
  • 约 16页
  • 2017-05-08 发布于上海
  • 举报

Visualisation of variable binding pockets on protein surfaces by probabilistic analysis of related structure sets 英文论文文献.doc

Visualisation of variable binding pockets on protein surfaces by probabilistic analysis of related structure sets 英文论文文献

Ashfordetal.BMCBioinformatics2012,13:39 /1471-2105/13/39 METHODOLOGY ARTICLE OpenAccess Visualisationofvariablebindingpocketson proteinsurfacesbyprobabilisticanalysisof relatedstructuresets PaulAshford1,DavidSMoss1,AlexanderAlex2,SiewKYeap2,AlicePovia1,IreneNobeli1* andMarkAWilliams1* Abstract Background:Proteinstructuresprovideavaluableresourceforrationaldrugdesign.Foraproteinwithnoknownligand, computationaltoolscanpredictsurfacepocketsthatareofsuitablesizeandshapetoaccommodateacomplementary small-moleculedrug.However,pocketpredictionagainstsinglestaticstructuresmaymissfeaturesofpoc

您可能关注的文档

文档评论(0)

1亿VIP精品文档

相关文档