三种方案治疗慢性支气管炎急性发作的成本-效果分析.pdfVIP

.878. 中国基层医药2014 年3 月第21 卷第6 期 Chin J Prim Med Pharm ,March 2014 ,Vol. 21 ,NQ. 6 三种方案治疗慢性支气管炎急性发作的 成本-效果分析 郑宏亮钟松阳徐展翅 [摘要] 目的 从药物经济学的角度分析和比较兰种方案:莫西沙星组、莫西沙星联合氨澳索组、阿奇 霉素联合左氧氟沙星组，治疗慢性支气管炎急性发作(AECB) 的临床疗效、安全性、依从性及经济效果。 方法 检索中国期刊全文数据库、万方医学数据库及中文科技期刊全文数据库，纳入三种方案对慢性支气管 炎急性发作治疗的随机对照试验(RCT) 文献，通过数据的分析来对药物做出经济学评价。结果 三种方案的 总有效率分别为94.92% 、95.08% 、 94.909昏，差异均无统计学意义(P 0. 05) ，成本效果比分别为213.34、 536.40 、61. 22。结论 三种治疗方案疗效相近，阿奇霉素与左氧氟沙星联合使用时具有经济学优势。 [关键词】 支气管炎，慢d性;成本-效果分析 Cost-effectivenes回 analysis of three kinds of schemes in the treatment of acute exacerbation of chronic bron- chitis Zheng Hongliang ,Zhong Songyang ,Xu Zhanchi. Department of Pharma句， the People s Hospital of Q归hou ， 。旧lwu ,Zhejiang 324000 ,China [ Abstraèt J Objective From the point of v町w of phalmaceutical economics , 10 analyze and compare the clinical efficacy ,safety ,compliance and economic effect of three kinds of scheme: 1. moxifloxacin , 2. moxifloxacin combined with ambroxol , 3. azithromycin combined with levofloxacin in the treatment of acute exacerbation of chronic bronchitis (AECB). Methods Retrieval Chinese joumal fulI-text database , Wanfang medical database and Chinese science and technology periodical full-text database ,included three options for the treatment of AECB randomized con- tro lIed trial (RCT) literature ,through the analysis of the data to make drug economics evaluation. Results The total effective rates of three programs were 94. 92% ,95. 08% ,94. 90% , the difference was not statistica1 1y significant (P O. 05). The cost-effectiveness ratios were 213.34 ,536.40 ,6 1. 22. Conclusion 四le efficacy of three treatmenl options is similar , azithromycin comhined 时th levofloxacin has economic advantages. 1Key words J Bronchitis 慢性支气管炎以咳嗽、咳痰或伴有气喘等反复 疗组、阿奇霉素与左氧氟沙星联合治疗组。 (4) 结 发作为主要症状，每年持续3 个月以上，连续2 年或